Publications & Press

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 *co-first authors          ⁺⁺co-corresponding authors         click on link to article

Multisensory Flicker Modulates Widespread Brain Networks and Reduces Interictal Epileptiform Discharges
Blanpain LT, Chen E, Park J., Walelign MY, Gross RE, Cabaniss BT, Willie JT⁺⁺, Singer AC⁺⁺ (2024)
Nature Communications
https://doi.org/10.1101/2023.03.14.23286691
medRxiv  https://doi.org/10.1101/2023.03.14.23286691

New information triggers prospective codes to adapt for flexible navigation.
Prince SM, Yassine TA, Katragadda N, Roberts TC, Singer AC  (2023)
bioRxiv
https://biorxiv.org/cgi/content/short/2023.10.31.564814v1

Brain rhythms control microglial response and cytokine expression via NFκB signaling. 
Prichard A⁺, Garza KM⁺, Shridhar A, He C, Bitfaran S, Wang Y, Goodson MC, Jaeger D, Wood LB⁺⁺, Singer AC⁺⁺ (2023)
Science Advances
https://doi.org/10.1126/sciadv.adf5672

Learning from inhibition: Functional roles of hippocampal inhibition in spatial and episodic learning and memory.
Jeong N, Singer AC (2022)
Current Opinion in Neurobiology
https://doi.org/10.1016/j.conb.2022.102604

Goal discrimination in hippocampal non-place cells when place information is ambiguous.
Zhang, L, Prince SM, Paulson AL, Singer AC (2022)
Proceedings of the National Academy of Sciences
https://doi.org/10.1073/pnas.2107337119

A feasibility trial of gamma sensory Flicker for patients with prodromal Alzheimer’s Disease.
He Q, Colon-Motas K, Pybus A, Piendel L, Seppa J, Walker M, Manzanares C, Qui D, Miocinovic S, Wood L, Levey A, Lah J, Singer AC (2021)
Alzheimer’s & Dementia: TRCI
https://doi.org/10.1002/trc2.12178

Alzheimer’s pathology causes impaired inhibitory connections and reactivation of place codes during spatial navigation
Prince SM, Paulson AL, Jeong N, Amigues S, Singer AC (2021)
Cell Reports
https://doi.org/10.1016/j.celrep.2021.109008

Gamma visual stimulation induces a neuroimmune signaling profile distinct from acute neuroinflammation.
Garza K, Zhang L, Boron B, Attokaren M,Wood L⁺⁺, Singer AC⁺⁺ (2020)
Journal of Neuroscience
https://doi.org/10.1523/JNEUROSCI.1511-19.2019

Sub-second Dynamics of Theta-Gamma Coupling in Hippocampal CA1.
Zhang L, J Lee , CJ Rozell, AC Singer (2019)
eLife
https://elifesciences.org/articles/44320

Multi-sensory gamma stimulation ameliorates Alzheimer’s-associated pathology and improves cognition.
Martorell AJ*, AL Paulson*, H-J Suk, F Abdurrob, GT Drummond, W Guan, JZ Young, DN-W Kim, O Kritskiy, SJ Baker, V Mangena, SM Prince, EN Brown, KC Chung, ES Boyden, AC Singer, L-H Tsai (2019)
Cell
https://www.cell.com/cell/fulltext/S0092-8674(19)30163-1

Non-invasive 40 Hz light flicker to reduce amyloid load and recruit microglia.
Singer AC⁺⁺, AJ Martorell, JM Douglas, F Abdurrob, M Attokaren, J Tipton, H Mathys, C Adaikkan, and L-H Tsai⁺⁺ (2018)
Nature Protocols
https://www.nature.com/articles/s41596-018-0021-x

Multi-neuron intracellular recording in vivo via interacting autopatching robots.
Kodandaramaiah SB*, FJ Flores*, GL Holst, AC Singer, X Han, EN Brown, ES Boyden, CR Forest (2018)
eLife
doi: https://doi.org/10.7554/eLife.24656.

Evidence for long-timescale patterns of synaptic inputs in CA1 of awake behaving mice.
Kolb I*, Franzesi GT*, M Wang, SB Kodandaramaiah, CR Forest, ES Boyden ⁺⁺, AC Singer ⁺⁺ (2017)
Journal of Neuroscience
doi: https://doi.org/10.1523/JNEUROSCI.1519-17.2017. PMID: 29279309

Illuminating Neural Circuits: From Molecules to MRI.
Lee JH, A Kreitzer, AC Singer, N Schiff (2017)
Journal of Neuroscience, featured article on symposium in Annual Meeting issue
doi: https://doi.org/10.1523/JNEUROSCI.2569-17.2017. PMID: 29118210

Mesoscale activated states gate spiking in the awake brain.
Singer AC*, GT Franzesi*, SB Kodandaramaiah, Cohen JD, Lee AK, Borgers C, Forest CR, NJ Kopell, ES Boyden (2017)
Journal of Neurophysiology
doi: 10.1152/jn.00116.2017. PMID: 28566460.

Gamma oscillations attenuate amyloid pathology and trigger a distinct microglia response in a mouse model of Alzheimer’s disease.
Iaccarino HF*, Singer AC*, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai L-H (2016)
Nature
doi: 10.1038/nature20587. PMID: 27929004.
Published with News and Views. Recommended on Faculty of 1000.

Autopatching: assembling and using a robot for automated intracellular neural recording in live mammalian brain.
Kodandaramaiah SB, IR Wickersham, GB Holst, AC Singer, G Talei-Franzesi, CR Forest, ES Boyden (2016)
Nature Protocols
doi: 10.1038/nprot.2016.007. PMID: 26938115.

Principles of Designing Interpretable Optogenetic Behavior Experiments.
BD Allen*, Singer AC*, ES Boyden (2015)
Learning and Memory.
doi: 10.1101/lm.038026.114. PMID: 25787711.
Invited article.

Hippocampal SWR activity predicts correct decisions during the initial learning of an alternation task.
Singer AC, MF Carr, MP Karlsson, LM Frank (2013)
Neuron
doi: 10.1016/j.neuron.2013.01.027. PMID: 23522050.
Featured article.

Experience dependent development of coordinated hippocampal spatial activity representing the similarity of related locations.
Singer AC, MP Karlsson, AR Nathe, MF Carr, LM Frank (2010)
Journal of Neuroscience
doi: 10.1523/JNEUROSCI.0926-10.2010. PMID: 20810880

Rewarded outcomes enhance reactivation of experience in the hippocampus.
Singer AC and LM Frank (2009)
Neuron
doi: 10.1016/j.neuron.2009.11.016. PMID: 20064396.
Cover article.

Selected Press Highlighting Our Research

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Joshua Stewart (2022) “Oft-Ignored ‘Non-Place’ Brain Cells Play a Crucial Role in Helping Navigate to the Right Goal” Coulter BME

James Kingsland (2021) “Can flickering light and sound treat Alzheimer’s?” Medical News Today

Chelsea W. Burker (2021) “Does Synchronizing Brain Waves Bring Harmony?” ALZForum

Jaye Watson (2020) Episode of Your Fantastic Mind on Georgia Public Broadcasting

Douglas Fields (2020) “Spreading the Word on a Possible Alzheimer’s Treatment.”Quanta Magazine

Melanie Falcon (2020) “Health Beat: Flickering lights to treat Alzheimer’s?” on WFMZ-TV69 News in Pennsylvania and New Jersey

Ivanhoe Broadcast News (2020) “Best Life: Flickering lights to treat Alzheimer’s?” on WMC5 News in Tennessee.

Photonics Media (2020) “Flickering Light Mobilizes Brain Chemistry That May Fight Alzheimer’s”

Teresia Minjoliand Trieneke Klein (2019) “Puzzling forgetting – new hope in Alzheimer’s.” Taglichtmedia Documentary on Alzheimer’s Disease for German Public Television.

Nancy Badertscher (2019) “Emory’s innovative Flicker Study flashes new light.”The Atlanta Journal-Constitution

Gwyneth Dickey Zakaib (2019) Flash! Beep! Gamma Waves Stimulate Microglia, Memory. AlzForum

Pam Belluck (2019) A Possible Alzheimer’s Treatment With Clicks and Flashes? It Worked on Mice.The New York Times

Steve McLaughlin (2019) Decoding Memory with Annabelle Singer.“The Uncommon Engineer” Podcast

Windell J (2017) What’s the Frequency? The Biomedical Scientist.

Lewis L (2017) A New Way to Approach Alzheimer’s: From the Beginning. Georgia Tech Engineers.

Webster M (2016) “Bringing Gamma Back.” Radiolab.

Yong E (2016) “Beating Alzheimer’s With Brain Waves.” The Atlantic.

Zakaib G (2016) “Flashy Treatment Synchronizes Neurons, Lowers Aβ in Mice.” ALZForum.

Healy M (2016) “Flickering lights may illuminate a path to Alzheimer’s treatment.” LA Times.

Roberts M (2016) “‘Flashing light therapy’ for Alzheimer’s.” BBC News.

Aron L & Yankner BA (2016) “Neurodegenerative disorders:
Neural synchronization in Alzheimer’s disease.” Nature 540, 207–208.

Singer W (2016) “F1000Prime Recommendation of Iaccarino HF, Singer AC et al. Nature 2016.” F1000Prime.

Hughes V (2014) “Mental Leaps Cued by Memory’s Ripples.” Quanta Magazine.

Robinson A (2014) “MIT Neurotech: Tapping into Neurons with Autopatching.” Scientific American.

Eichenbaum H (2013) “Hippocampus: remembering the choices.” Neuron, 77(6): 999–1001. Preview article.

Wagstaff K (2012) “Robot That Connects to Neurons Could Provide Key to Understanding the Human Brain.” Time.

Invited Talks

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Invited talks at the National Academy of Engineering, Stanford, Rice University, University of California, San Francisco, American Academy of Neurology Annual Meeting, Society for Neuroscience Annual Meeting, Federation of the European Neuroscience Societies Annual Meeting, EU-US Frontiers of Engineering Symposium, Arizona State University, Humbolt University of Berlin, Charité–Universitätsmedizin Berlin, Cannes Lions International Festival of Creativity, University of Florida, NIA Alzheimer’s Disease Center Directors’ Meeting, Annual Meeting of the Japan Neuroscience Society, International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD), Annual Meeting of the American Neurological Association, Cognitive Neuroscience Society (CNS) Annual Meeting Symposium, National Academy of Sciences Chinese-American Kavli Frontiers of Science, BrainModes 2019, Packard Foundation, DBS Think Tank 2018, MIT Symposium “Brain Rhythms in Health and Disease,” “Mechanisms of Learning Forum” at Emory University, NIH Symposium: “Innovations in Imaging to Advance Aging Research,” Society for Neuroscience symposium “Illuminating Neural Circuits: From Molecules to MRI,” Harvard Medical School, Princeton University, Janelia Farm Research Campus of the Howard Hughes Medical Institute, Georgia Institute of Technology, Brown University, Boston University, Emory University, Massachusetts Institute of Technology, the Memory and Aging Center at UCSF, and the Center for Visual and Neurocognitive Rehabilitation at the U.S. Department of Veterans Affairs.