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Decoding Memory In Health and Disease

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NAE Invites Singer to Deliver Gilbreth Lecture at 2022 National Meeting

Annabelle Singer
December 21, 2021

Singer has received a Gilbreth Lectureship from the National Academy of Engineering (NAE) and will present her work on neural stimulation for Alzheimer’s patients at the Academy’s 2022 national meeting in Irvine, California.  Read more here The Gilbreth Lectures were established in 2001 by the Council of the National Academy of Engineering as a means…

Full Post NAE Invites Singer to Deliver Gilbreth Lecture at 2022 National Meeting

Congratulations to Tina Franklin for Alzheimer’s Association Fellowship

Annabelle Singer
November 18, 2021

Congratulations to Dr. Tina Franklin for being awarded an Alzheimer’s Association Research Fellowship! Thank you  Alzheimer’s Association for supporting this groundbreaking research at the intersection of stress, inflamm-aging, and neurodegenerative disease.

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Congratulations to Stephanie Prince for TWO scientific awards

Annabelle Singer
November 18, 2021

Big congratulations to Stephanie Prince for being awarded the Emory Neuroscience Program Scholar of the year AND Outstanding Scientific Achievement Award!  Steph has some very cool science in the works. Check out her paper from earlier this year here.  

Full Post Congratulations to Stephanie Prince for TWO scientific awards

Singer wins Derek Denny-Brown Young Neurological Scholars Award from the American Neurological Association

Annabelle Singer
July 26, 2021

The American Neurological Association has recognized Annabelle Singer for achieving significant stature in neurological research and demonstrating the promise of major contributions to come. Singer has received a Derek Denny-Brown Young Neurological Scholars Award from the association and will deliver a talk about her work virtually in October at the association’s 2021 national meeting. Read…

Full Post Singer wins Derek Denny-Brown Young Neurological Scholars Award from the American Neurological Association

New Paper: A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer’s disease

Annabelle Singer
June 9, 2021

Our human trial of gamma sensory stimulation or “flicker” in human Alzheimer’s patients based on our animal studies is now published:  https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12178 This was an illuminating (pun intended) collaboration the clinical team at EmoryBrain Health Center led by James Lah and Allan Levey and the Wood lab and Singer lab at Georgia Tech. In planning the…

Full Post New Paper: A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer’s disease

New Paper: Alzheimer’s pathology causes impaired inhibitory connections and reactivation of spatial codes during spatial navigation

Annabelle Singer
June 9, 2021

Our new paper lead by Stephanie Prince is published and featured on the cover of Cell Reports.  We found weaker inhibitory synaptic connections onto pyramidal neurons in CA1 during navigation in a mouse model of Alzheimer’s disease. Synaptic dysfunction is thought key to memory impairment in Alzheimer’s disease but is typically studied in slice or…

Full Post New Paper: Alzheimer’s pathology causes impaired inhibitory connections and reactivation of spatial codes during spatial navigation

Qiliang He earns Warren Alpert Distinguished Scholar Award

Matthew Goodson
March 11, 2021

Congratulations to postdoctoral fellow, Dr. Qiliang He for being granted a Warren Alpert Distinguished Scholar Fellowship Award  for the continuation of his work on the reversal of age-related memory damage. Read the whole story [HERE!]  

Full Post Qiliang He earns Warren Alpert Distinguished Scholar Award

Abby Paulson receives J. Norman and Rosalyn Wells Fellowship Award

Matthew Goodson
March 9, 2021

Congratulations, Abby Paulson for receiving J. Norman and Rosalyn Wells Fellowship Award; granted for conducting meritorious research in the areas of neuroengineering or brain tumors.

Full Post Abby Paulson receives J. Norman and Rosalyn Wells Fellowship Award

Dr. Singer wins Trubatch Career Development Award from SFN

Annabelle Singer
January 19, 2021

Dr. Annabelle Singer has been named a recipient of the prestigious Jannett Rosenberg Trubatch Career Development Award from the Society for Neuroscience (SfN). The Trubatch Award recognizes early-career researchers who have demonstrated great originality and creativity in their work.  Congratulations to all the 2020 awardees!     More on the 2020 Trubatch Career Development Award…

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Your Fantastic Mind Episode on Memory

Annabelle Singer
October 13, 2020

On Wednesday Oct 14th at 7PM on Your Fantastic Mind, our research will be included in an episode on Memory showing on PBS. You can also find episodes here after broadcast

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Nuri Jeong awarded Research Fellowship in Neuroscience

Matthew Attokaren
July 26, 2020

Congratulations to Nuri Jeong for receiving the Michael Kuhar Graduate Fellowship in Neuroscience!

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Dr. Singer selected for National Academy of Engineering’s (NAE) 2020 EU-US Frontiers of Engineering Symposium.

Matthew Attokaren
April 22, 2020

Dr. Singer selected for the National Academy of Engineering’s (NAE) 2020 EU-US Frontiers of Engineering Symposium. More info here: https://bme.gatech.edu/bme/annabelle-singer-invited-join-nations-brightest-young-engineers-2020-eu-us-frontiers-engineering

Full Post Dr. Singer selected for National Academy of Engineering’s (NAE) 2020 EU-US Frontiers of Engineering Symposium.

New paper: Research Articles, Cellular/Molecular Gamma Visual Stimulation Induces a Neuroimmune Signaling Profile Distinct from Acute Neuroinflammation

Matthew Attokaren
February 2, 2020

The Journal of Neuroscience has published Kristie Garza’s paper: Cellular/Molecular Gamma Visual Stimulation Induces a Neuroimmune Signaling Profile Distinct from Acute Neuroinflammation. This paper shows how visual stimulation rapidly induces critical neuroimmune signaling in healthy animals. Paper here: https://www.jneurosci.org/content/40/6/1211 News articles featuring this research: https://www.sciencedaily.com/releases/2020/02/200203141446.htm https://jneurosci.altmetric.com/details/74951155/news  

Full Post New paper: Research Articles, Cellular/Molecular Gamma Visual Stimulation Induces a Neuroimmune Signaling Profile Distinct from Acute Neuroinflammation

Dr Singer presents at Alzheimer’s Disease Centers Fall 2019 Directors meeting and received Junior Investigators Presentation Award from the NIA.

Matthew Attokaren
November 22, 2019

Dr. Singer presents at Alzheimer’s Disease Centers Fall 2019 Directors meeting and received the Junior Investigators Presentation Award from the NIA.

Full Post Dr Singer presents at Alzheimer’s Disease Centers Fall 2019 Directors meeting and received Junior Investigators Presentation Award from the NIA.

Stephanie Prince accepted to attend NSF Cyber Carpentry Workshop.

Matthew Attokaren
November 3, 2019

Stephanie Prince accepted to attend NSF Cyber Carpentry Workshop. More info here: https://sils.unc.edu/news/2019/cyber-carpentry

Full Post Stephanie Prince accepted to attend NSF Cyber Carpentry Workshop.

Kristie Garza named an SFN Neuroscience Scholars Program Associate

Matthew Attokaren
November 2, 2019

Kristie Garza named an SFN Neuroscience Scholars Program Associate for 2019-2021. Congrats, Kristie! More info here: https://www.sfn.org/initiatives/diversity-programs/neuroscience-scholars-program  

Full Post Kristie Garza named an SFN Neuroscience Scholars Program Associate

Online Journal Club of our recent paper

Annabelle Singer
October 1, 2019

Check out Lu Zhang presenting his paper “Sub-second dynamics of theta-gamma coupling in hippocampal CA1” in JRNLclub, an online journal club: https://jrnlclub.org/research-films/sub-second-dynamics-theta-gamma-coupling

Full Post Online Journal Club of our recent paper

German Documentary Highlighting our Flicker study

Annabelle Singer
September 18, 2019

Dr. Singer and colleagues were interviewed for a German documentary “Puzzling forgetting – new hope in Alzheimer’s.” The documentary will air Thursday 9/19 on 3sat at 8:15PM. Full video and more information (in German) here: https://www.3sat.de/wissen/wissenschaftsdoku/raetselhaftes-vergessen-100.html And here: https://www.facebook.com/3sat.de/videos/1091711534368653/?epa=SEARCH_BOX

Full Post German Documentary Highlighting our Flicker study

Congratulations Abby on receiving the F31 predoctoral fellowship!

Annabelle Singer
September 11, 2019

Congratulations to Abby Paulson for receiving an F31 pre-doctoral training fellowship from the NIA.  The project, entitled “Effects of non-invasive gamma stimulation on hippocampal neural codes in a mouse model of Alzheimer’s disease” builds on her prior work, a collaboration with Anthony Martorell that was published earlier this year in Cell. Well done Abby!

Full Post Congratulations Abby on receiving the F31 predoctoral fellowship!

New paper: Sub-second Dynamics of Theta-Gamma Coupling in Hippocampal CA1.

Annabelle Singer
August 16, 2019

Lu’s paper is published in eLife.  Click to check it out or go here: https://elifesciences.org/articles/44320 This paper reports new methods to examine oscillatory brain activity (or brain waves), which are thought to play a key role in how different brain regions communicate. These brain waves, which are altered in many diseases, can be thought of like walkie talkies…

Full Post New paper: Sub-second Dynamics of Theta-Gamma Coupling in Hippocampal CA1.

Singer Lab study featured in Atlanta Journal Constitution

Annabelle Singer
June 18, 2019

Our study with the Emory Brain Health Center was featured in a recent edition of the Atlanta Journal Constitution:

Full Post Singer Lab study featured in Atlanta Journal Constitution

Anthony and Abby’s paper is covered in the New York Times

Annabelle Singer
March 15, 2019

Anthony and Abby’s Cell paper is covered in the New York Times: An especially insightful write up and commentary from AlzForum: Flash! Beep! Gamma Waves Stimulate Microglia, Memory

Full Post Anthony and Abby’s paper is covered in the New York Times

New Paper in Cell arising from our collaboration with Li-Huei Tsai’s group

Annabelle Singer
March 15, 2019

Congratulations to Anthony Martorell (Li-Huei Tsai’s lab) and Abby Paulson (my lab), co-first authors of this cool new paper in Cell. In short: auditory + visual sensory flicker stimulate rhythmic activity in deep brain regions that are hard to reach with existing non-invasive stimulation, like the hippocampus and prefrontal cortex. Gamma frequency multi-sensory flicker (but…

Full Post New Paper in Cell arising from our collaboration with Li-Huei Tsai’s group

Nuri Jeong awarded YITP Award

Matthew Attokaren
February 15, 2019

Congratulations to Nuri Jeong for winning a Young Investigator Training Program award for the 10th IBRO World Congress of Neuroscience in Daegu, Korea this year.  Great job, Nuri!  

Full Post Nuri Jeong awarded YITP Award

Dr. Singer Speaks with the Dean of Engineering about Memory

Annabelle Singer
February 3, 2019

Annabelle Singer and Dean McLaughlin discuss memory, Alzheimer’s, and our research in the Dean’s podcast, The Uncommon Engineer:           Listen to more episodes of the Dean’s Uncommon Engineer series here:

Full Post Dr. Singer Speaks with the Dean of Engineering about Memory

Singer selected as National Academy of Sciences Kavli Fellow

Annabelle Singer
October 22, 2018

As a National Academy of Sciences Kavli Fellow, Dr. Singer attended the 18th Chinese-American Kavli Frontiers of Science symposium in Nanjing, China. The Kavli Frontiers of Science symposium series (KFoS) is the Academy’s premiere activity for distinguished young scientists.  Kavli Frontiers of Science symposia bring together outstanding young scientists to discuss exciting advances and opportunities in a…

Full Post Singer selected as National Academy of Sciences Kavli Fellow

Steph awarded SFN Trainee Professional Development Award

Annabelle Singer
September 14, 2018

Congratulations to Steph Prince for being selected for the SFN Trainee Professional Development Award.  More details here.  

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Singer lab awarded NIH grant

Annabelle Singer
September 12, 2018

The Singer lab was awarded a 5-year grant from the NIH National Institute for Neurological Disorders and Stroke (NINDS).  We are grateful to the NIH for it’s continued support of basic research.

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Singer talk broadcast on Facebook Live

Annabelle Singer
August 31, 2018

Tune in to the Packard Foundation’s Facebook page for live coverage of Dr. Singer and other Fellows’ presentations on Thursday, September 6 from 10:40-11:20 AM PST. Share with your lab and colleagues!

Full Post Singer talk broadcast on Facebook Live

Singer Highlighted in GT President’s Annual Address

Annabelle Singer
August 31, 2018

Dr. Singer was highlighted in Georgia Tech President Bud Petersen’s Annual Address to the Institute.  See the slides here.

Full Post Singer Highlighted in GT President’s Annual Address

New Paper: Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load

Annabelle Singer
August 13, 2018

Our new paper in Nature Protocols describes a non-invasive approach to evoke microglia engulfment and reduce amyloid levels in the mouse brain. We describe how to assemble and operate a custom-made 40 Hz light flicker system and downstream analysis of the molecular and cellular effects.  Read more here

Full Post New Paper: Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load

Abigail Paulson selected for T32 Training Grant

Matthew Attokaren
May 25, 2018

Congratulations to Abigail Paulson for being selected to be funded by Dr. Levey’s T32 training grant: “Training in translational Research in Neurology”.  Great job, Abby!

Full Post Abigail Paulson selected for T32 Training Grant

Dr. Rafeal Bras recounts memories of a friend & how GT Professors are cracking the mysteries of Alzheimer’s

Matthew Attokaren
April 22, 2018

Georgia Tech Provost, Dr. Rafael Bras, recounts the memories of a friend diagnosed with Alzheimer’s and describes how Georgia Tech professors are trying to crack the mysteries of the disease. Link to the original post:  http://www.provost.gatech.edu/blog/death-friend “One of my best friends just passed away. We went way back a long way. He was a big, funny,…

Full Post Dr. Rafeal Bras recounts memories of a friend & how GT Professors are cracking the mysteries of Alzheimer’s

A visit from the Queen Bee, GT First Lady Val Peterson and the spouses of the Georgia Board of Regents

Matthew Attokaren
April 17, 2018

Today we hosted GT First Lady, Val Peterson and spouses of the Georgia Board of Regents.  Abby gave a presentation about our lab research, and Matty and Abby gave them a tour of the Neurolab.

Full Post A visit from the Queen Bee, GT First Lady Val Peterson and the spouses of the Georgia Board of Regents

Annabelle presents at MIT Symposium “Brain Rhythms in Health and Disease”

Matthew Attokaren
April 4, 2018

Symposium speaks to the many powers of brain rhythms: When neuroscientists fresh from the lab mention the power of brain rhythms, they usually mean the amplitude of the waves they just measured, but when 11 renowned experts convened before a standing-room-only audience at the Picower Institute for Learning and Memory April 4, they made the…

Full Post Annabelle presents at MIT Symposium “Brain Rhythms in Health and Disease”

Congratulations to Stephanie Prince for winning the NSF award!

Matthew Attokaren
April 3, 2018

Stephanie Prince was awarded a Fellowship from the National Science Foundation.  Congrats, Steph!

Full Post Congratulations to Stephanie Prince for winning the NSF award!

Neurons Get the Beat and Keep It Going in Drumrolls

Annabelle Singer
March 1, 2018

This article describes our recent paper: “Some of what researchers believed to be chaotic electric potentials in neurons are turning out the be surprisingly orderly. A neuron firing deep in the brain might sound a little like: Drumroll…cymbal crash! Drumroll…cymbal crash! Repeat. With emphasis on “repeat,” according to a new study. What used to look…

Full Post Neurons Get the Beat and Keep It Going in Drumrolls

Multi-neuron intracellular recording in vivo via interacting autopatching robots

Matthew Attokaren
January 3, 2018

The activities of groups of neurons in a circuit or brain region are important for neuronal computations that contribute to behaviors and disease states. Traditional extracellular recordings have been powerful and scalable, but much less is known about the intracellular processes that lead to spiking activity. We present a robotic system, the multipatcher, capable of…

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New Article: Evidence for long-timescale patterns of synaptic inputs in CA1 of awake behaving mice

Matthew Attokaren
December 26, 2017

Repeated sequences of neural activity are a pervasive feature of neural networks in vivo and in vitro. In the hippocampus, sequential firing of many neurons over 100-300 ms periods re-occurs during behavior and during periods of quiescence. However, it is not known whether the hippocampus produces longer sequences of activity or whether such sequences are…

Full Post New Article: Evidence for long-timescale patterns of synaptic inputs in CA1 of awake behaving mice

Illuminating Neural Circuits: From Molecules to MRI

Matthew Attokaren
November 8, 2017

Neurological disease drives symptoms through pathological changes to circuit functions. Therefore, understanding circuit mechanisms that drive behavioral dysfunction is of critical importance for quantitative diagnosis and systematic treatment of neurological disease. Here, we describe key technologies that enable measurement and manipulation of neural activity and neural circuits. Applying these approaches led to the discovery of…

Full Post Illuminating Neural Circuits: From Molecules to MRI

Singer named Packard Fellow

Annabelle Singer
October 16, 2017

Georgia Tech researcher one of 18 innovative young scientists in the nation to receive prestigious honor October 16, 2017 (Los Altos, CA) – Annabelle Singer, assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University, was named today by the David and Lucile Packard Foundation…

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WHAT’S THE FREQUENCY?

Matthew Attokaren
September 3, 2017

From The Biomedical Scientist “Finding a treatment for Alzheimer’s disease, the most common cause of dementia, is one of the key challenges for modern science, and a research team in the US might have made a significant breakthrough. The team’s paper, Gamma frequency entrainment attenuates amyloid load and modifies microglia, was published at the end of…

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New Paper: Mesoscale-duration activated states gate spiking in response to fast rises in membrane voltage in the awake brain

Matthew Attokaren
August 30, 2017

Published Tue, 01 Aug 2017 in Journal of Neurophysiology “Seconds-scale network states, affecting many neurons within a network, modulate neural activity by complementing fast integration of neuron-specific inputs that arrive in the milliseconds before spiking. Nonrhythmic subthreshold dynamics at intermediate timescales, however, are less well characterized. We found, using automated whole cell patch clamping in vivo, that…

Full Post New Paper: Mesoscale-duration activated states gate spiking in response to fast rises in membrane voltage in the awake brain

Killing the Mind First

Matthew Attokaren
August 30, 2017

By Ben Brumfield | Published July 6, 2017 “When George Wright buried his wife, Beth, in 2013, he was probably easing into the same illness that had killed her at age 84. But his adult children hadn’t yet noticed that he, too, had Alzheimer’s disease. Their eyes had been fixed on their mother while her mind unraveled,…

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Congratulations to Abby Paulson for winning the Elder Health Scholarship

Matthew Attokaren
August 30, 2017

Abby Paulson won the Elder Health Scholarship from the Residential Care Facilities for the Elderly Authority of Fulton County for her outstanding academic record and her commitment to and potential for leadership in the field of aging.

Full Post Congratulations to Abby Paulson for winning the Elder Health Scholarship

Cosmos in the Cranium

Matthew Attokaren
August 30, 2017

Article By Ben Brumfield “The human brain is believed to have more than 160 billion cells; more than half of them are neurons. And they often share thousands of connections with neighboring neurons to form somewhere between 100 trillion and a quadrillion circuits flashing day and night. That’s many hundreds of times more circuits than there…

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A New Way to Approach Alzheimer’s: From the Beginning

Annabelle Singer
March 13, 2017

A new article about our research: Story by Lyndsey Lewis Photos by Gary Meek “Annabelle Singer’s research could revolutionize the way we look at the disease’s progression. If you keep up with medical news, you’ve probably heard of beta amyloid. It plays the villain in plenty of stories about Alzheimer’s disease: One of the signature…

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New paper: An innovative and groundbreaking approach to combating Alzheimer’s

Shirin Kale
December 8, 2016

Newly published in Nature : “Gamma frequency entrainment attenuates amyloid load and modifies microglia.” Disrupted gamma rhythms—oscillations in the brain’s neuronal circuits at around 20–50 Hz—are hallmarks of various neurological disorders and have been seen in patients with Alzheimer’s disease and specific mouse models of the disease. We show that gamma oscillations are also disrupted…

Full Post New paper: An innovative and groundbreaking approach to combating Alzheimer’s

Bettina Arkhurst won the Laya Wiesner Award

Annabelle Singer
June 5, 2016

Congratulation to Bettina Arkhurst who was awarded the Laya Wiesner Community Award.

Full Post Bettina Arkhurst won the Laya Wiesner Award

Recording robots are in the news

Annabelle Singer
June 5, 2016

In Nature, Helen Shen writes about robots recording brain activity inside neurons highlighting our work.  

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