News
NAE Invites Singer to Deliver Gilbreth Lecture at 2022 National Meeting
Singer has received a Gilbreth Lectureship from the National Academy of Engineering (NAE) and will present her work on neural stimulation for Alzheimer’s patients at the Academy’s 2022 national meeting in Irvine, California. Read more here The Gilbreth Lectures were established in 2001 by the Council of the National Academy of Engineering as a means…
Full Post NAE Invites Singer to Deliver Gilbreth Lecture at 2022 National Meeting
Congratulations to Tina Franklin for Alzheimer’s Association Fellowship
Congratulations to Dr. Tina Franklin for being awarded an Alzheimer’s Association Research Fellowship! Thank you Alzheimer’s Association for supporting this groundbreaking research at the intersection of stress, inflamm-aging, and neurodegenerative disease.
Full Post Congratulations to Tina Franklin for Alzheimer’s Association Fellowship
Congratulations to Stephanie Prince for TWO scientific awards
Big congratulations to Stephanie Prince for being awarded the Emory Neuroscience Program Scholar of the year AND Outstanding Scientific Achievement Award! Steph has some very cool science in the works. Check out her paper from earlier this year here.
Full Post Congratulations to Stephanie Prince for TWO scientific awards
Singer wins Derek Denny-Brown Young Neurological Scholars Award from the American Neurological Association
The American Neurological Association has recognized Annabelle Singer for achieving significant stature in neurological research and demonstrating the promise of major contributions to come. Singer has received a Derek Denny-Brown Young Neurological Scholars Award from the association and will deliver a talk about her work virtually in October at the association’s 2021 national meeting. Read…
New Paper: A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer’s disease
Our human trial of gamma sensory stimulation or “flicker” in human Alzheimer’s patients based on our animal studies is now published: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12178 This was an illuminating (pun intended) collaboration the clinical team at EmoryBrain Health Center led by James Lah and Allan Levey and the Wood lab and Singer lab at Georgia Tech. In planning the…
New Paper: Alzheimer’s pathology causes impaired inhibitory connections and reactivation of spatial codes during spatial navigation
Our new paper lead by Stephanie Prince is published and featured on the cover of Cell Reports. We found weaker inhibitory synaptic connections onto pyramidal neurons in CA1 during navigation in a mouse model of Alzheimer’s disease. Synaptic dysfunction is thought key to memory impairment in Alzheimer’s disease but is typically studied in slice or…
Qiliang He earns Warren Alpert Distinguished Scholar Award
Congratulations to postdoctoral fellow, Dr. Qiliang He for being granted a Warren Alpert Distinguished Scholar Fellowship Award for the continuation of his work on the reversal of age-related memory damage. Read the whole story [HERE!]
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Abby Paulson receives J. Norman and Rosalyn Wells Fellowship Award
Congratulations, Abby Paulson for receiving J. Norman and Rosalyn Wells Fellowship Award; granted for conducting meritorious research in the areas of neuroengineering or brain tumors.
Full Post Abby Paulson receives J. Norman and Rosalyn Wells Fellowship Award
Dr. Singer wins Trubatch Career Development Award from SFN
Dr. Annabelle Singer has been named a recipient of the prestigious Jannett Rosenberg Trubatch Career Development Award from the Society for Neuroscience (SfN). The Trubatch Award recognizes early-career researchers who have demonstrated great originality and creativity in their work. Congratulations to all the 2020 awardees! More on the 2020 Trubatch Career Development Award…
Full Post Dr. Singer wins Trubatch Career Development Award from SFN
Your Fantastic Mind Episode on Memory
On Wednesday Oct 14th at 7PM on Your Fantastic Mind, our research will be included in an episode on Memory showing on PBS. You can also find episodes here after broadcast
Nuri Jeong awarded Research Fellowship in Neuroscience
Congratulations to Nuri Jeong for receiving the Michael Kuhar Graduate Fellowship in Neuroscience!
Full Post Nuri Jeong awarded Research Fellowship in Neuroscience
Dr. Singer selected for National Academy of Engineering’s (NAE) 2020 EU-US Frontiers of Engineering Symposium.
Dr. Singer selected for the National Academy of Engineering’s (NAE) 2020 EU-US Frontiers of Engineering Symposium. More info here: https://bme.gatech.edu/bme/annabelle-singer-invited-join-nations-brightest-young-engineers-2020-eu-us-frontiers-engineering
New paper: Research Articles, Cellular/Molecular Gamma Visual Stimulation Induces a Neuroimmune Signaling Profile Distinct from Acute Neuroinflammation
The Journal of Neuroscience has published Kristie Garza’s paper: Cellular/Molecular Gamma Visual Stimulation Induces a Neuroimmune Signaling Profile Distinct from Acute Neuroinflammation. This paper shows how visual stimulation rapidly induces critical neuroimmune signaling in healthy animals. Paper here: https://www.jneurosci.org/content/40/6/1211 News articles featuring this research: https://www.sciencedaily.com/releases/2020/02/200203141446.htm https://jneurosci.altmetric.com/details/74951155/news
Dr Singer presents at Alzheimer’s Disease Centers Fall 2019 Directors meeting and received Junior Investigators Presentation Award from the NIA.
Dr. Singer presents at Alzheimer’s Disease Centers Fall 2019 Directors meeting and received the Junior Investigators Presentation Award from the NIA.
Stephanie Prince accepted to attend NSF Cyber Carpentry Workshop.
Stephanie Prince accepted to attend NSF Cyber Carpentry Workshop. More info here: https://sils.unc.edu/news/2019/cyber-carpentry
Full Post Stephanie Prince accepted to attend NSF Cyber Carpentry Workshop.
Kristie Garza named an SFN Neuroscience Scholars Program Associate
Kristie Garza named an SFN Neuroscience Scholars Program Associate for 2019-2021. Congrats, Kristie! More info here: https://www.sfn.org/initiatives/diversity-programs/neuroscience-scholars-program
Full Post Kristie Garza named an SFN Neuroscience Scholars Program Associate
Online Journal Club of our recent paper
Check out Lu Zhang presenting his paper “Sub-second dynamics of theta-gamma coupling in hippocampal CA1” in JRNLclub, an online journal club: https://jrnlclub.org/research-films/sub-second-dynamics-theta-gamma-coupling
German Documentary Highlighting our Flicker study
Dr. Singer and colleagues were interviewed for a German documentary “Puzzling forgetting – new hope in Alzheimer’s.” The documentary will air Thursday 9/19 on 3sat at 8:15PM. Full video and more information (in German) here: https://www.3sat.de/wissen/wissenschaftsdoku/raetselhaftes-vergessen-100.html And here: https://www.facebook.com/3sat.de/videos/1091711534368653/?epa=SEARCH_BOX
Congratulations Abby on receiving the F31 predoctoral fellowship!
Congratulations to Abby Paulson for receiving an F31 pre-doctoral training fellowship from the NIA. The project, entitled “Effects of non-invasive gamma stimulation on hippocampal neural codes in a mouse model of Alzheimer’s disease” builds on her prior work, a collaboration with Anthony Martorell that was published earlier this year in Cell. Well done Abby!
Full Post Congratulations Abby on receiving the F31 predoctoral fellowship!
New paper: Sub-second Dynamics of Theta-Gamma Coupling in Hippocampal CA1.
Lu’s paper is published in eLife. Click to check it out or go here: https://elifesciences.org/articles/44320 This paper reports new methods to examine oscillatory brain activity (or brain waves), which are thought to play a key role in how different brain regions communicate. These brain waves, which are altered in many diseases, can be thought of like walkie talkies…
Full Post New paper: Sub-second Dynamics of Theta-Gamma Coupling in Hippocampal CA1.
Singer Lab study featured in Atlanta Journal Constitution
Our study with the Emory Brain Health Center was featured in a recent edition of the Atlanta Journal Constitution:
Full Post Singer Lab study featured in Atlanta Journal Constitution
Anthony and Abby’s paper is covered in the New York Times
Anthony and Abby’s Cell paper is covered in the New York Times: An especially insightful write up and commentary from AlzForum: Flash! Beep! Gamma Waves Stimulate Microglia, Memory
Full Post Anthony and Abby’s paper is covered in the New York Times
New Paper in Cell arising from our collaboration with Li-Huei Tsai’s group
Congratulations to Anthony Martorell (Li-Huei Tsai’s lab) and Abby Paulson (my lab), co-first authors of this cool new paper in Cell. In short: auditory + visual sensory flicker stimulate rhythmic activity in deep brain regions that are hard to reach with existing non-invasive stimulation, like the hippocampus and prefrontal cortex. Gamma frequency multi-sensory flicker (but…
Full Post New Paper in Cell arising from our collaboration with Li-Huei Tsai’s group
Nuri Jeong awarded YITP Award
Congratulations to Nuri Jeong for winning a Young Investigator Training Program award for the 10th IBRO World Congress of Neuroscience in Daegu, Korea this year. Great job, Nuri!
Dr. Singer Speaks with the Dean of Engineering about Memory
Annabelle Singer and Dean McLaughlin discuss memory, Alzheimer’s, and our research in the Dean’s podcast, The Uncommon Engineer: Listen to more episodes of the Dean’s Uncommon Engineer series here:
Full Post Dr. Singer Speaks with the Dean of Engineering about Memory
Singer selected as National Academy of Sciences Kavli Fellow
As a National Academy of Sciences Kavli Fellow, Dr. Singer attended the 18th Chinese-American Kavli Frontiers of Science symposium in Nanjing, China. The Kavli Frontiers of Science symposium series (KFoS) is the Academy’s premiere activity for distinguished young scientists. Kavli Frontiers of Science symposia bring together outstanding young scientists to discuss exciting advances and opportunities in a…
Full Post Singer selected as National Academy of Sciences Kavli Fellow
Steph awarded SFN Trainee Professional Development Award
Congratulations to Steph Prince for being selected for the SFN Trainee Professional Development Award. More details here.
Full Post Steph awarded SFN Trainee Professional Development Award
Singer lab awarded NIH grant
The Singer lab was awarded a 5-year grant from the NIH National Institute for Neurological Disorders and Stroke (NINDS). We are grateful to the NIH for it’s continued support of basic research.
Singer talk broadcast on Facebook Live
Tune in to the Packard Foundation’s Facebook page for live coverage of Dr. Singer and other Fellows’ presentations on Thursday, September 6 from 10:40-11:20 AM PST. Share with your lab and colleagues!
Singer Highlighted in GT President’s Annual Address
Dr. Singer was highlighted in Georgia Tech President Bud Petersen’s Annual Address to the Institute. See the slides here.
Full Post Singer Highlighted in GT President’s Annual Address
New Paper: Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load
Our new paper in Nature Protocols describes a non-invasive approach to evoke microglia engulfment and reduce amyloid levels in the mouse brain. We describe how to assemble and operate a custom-made 40 Hz light flicker system and downstream analysis of the molecular and cellular effects. Read more here
Abigail Paulson selected for T32 Training Grant
Congratulations to Abigail Paulson for being selected to be funded by Dr. Levey’s T32 training grant: “Training in translational Research in Neurology”. Great job, Abby!
Dr. Rafeal Bras recounts memories of a friend & how GT Professors are cracking the mysteries of Alzheimer’s
Georgia Tech Provost, Dr. Rafael Bras, recounts the memories of a friend diagnosed with Alzheimer’s and describes how Georgia Tech professors are trying to crack the mysteries of the disease. Link to the original post: http://www.provost.gatech.edu/blog/death-friend “One of my best friends just passed away. We went way back a long way. He was a big, funny,…
A visit from the Queen Bee, GT First Lady Val Peterson and the spouses of the Georgia Board of Regents
Today we hosted GT First Lady, Val Peterson and spouses of the Georgia Board of Regents. Abby gave a presentation about our lab research, and Matty and Abby gave them a tour of the Neurolab.
Annabelle presents at MIT Symposium “Brain Rhythms in Health and Disease”
Symposium speaks to the many powers of brain rhythms: When neuroscientists fresh from the lab mention the power of brain rhythms, they usually mean the amplitude of the waves they just measured, but when 11 renowned experts convened before a standing-room-only audience at the Picower Institute for Learning and Memory April 4, they made the…
Full Post Annabelle presents at MIT Symposium “Brain Rhythms in Health and Disease”
Congratulations to Stephanie Prince for winning the NSF award!
Stephanie Prince was awarded a Fellowship from the National Science Foundation. Congrats, Steph!
Full Post Congratulations to Stephanie Prince for winning the NSF award!
Neurons Get the Beat and Keep It Going in Drumrolls
This article describes our recent paper: “Some of what researchers believed to be chaotic electric potentials in neurons are turning out the be surprisingly orderly. A neuron firing deep in the brain might sound a little like: Drumroll…cymbal crash! Drumroll…cymbal crash! Repeat. With emphasis on “repeat,” according to a new study. What used to look…
Full Post Neurons Get the Beat and Keep It Going in Drumrolls
Multi-neuron intracellular recording in vivo via interacting autopatching robots
The activities of groups of neurons in a circuit or brain region are important for neuronal computations that contribute to behaviors and disease states. Traditional extracellular recordings have been powerful and scalable, but much less is known about the intracellular processes that lead to spiking activity. We present a robotic system, the multipatcher, capable of…
Full Post Multi-neuron intracellular recording in vivo via interacting autopatching robots
New Article: Evidence for long-timescale patterns of synaptic inputs in CA1 of awake behaving mice
Repeated sequences of neural activity are a pervasive feature of neural networks in vivo and in vitro. In the hippocampus, sequential firing of many neurons over 100-300 ms periods re-occurs during behavior and during periods of quiescence. However, it is not known whether the hippocampus produces longer sequences of activity or whether such sequences are…
Illuminating Neural Circuits: From Molecules to MRI
Neurological disease drives symptoms through pathological changes to circuit functions. Therefore, understanding circuit mechanisms that drive behavioral dysfunction is of critical importance for quantitative diagnosis and systematic treatment of neurological disease. Here, we describe key technologies that enable measurement and manipulation of neural activity and neural circuits. Applying these approaches led to the discovery of…
Full Post Illuminating Neural Circuits: From Molecules to MRI
Singer named Packard Fellow
Georgia Tech researcher one of 18 innovative young scientists in the nation to receive prestigious honor October 16, 2017 (Los Altos, CA) – Annabelle Singer, assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University, was named today by the David and Lucile Packard Foundation…
WHAT’S THE FREQUENCY?
From The Biomedical Scientist “Finding a treatment for Alzheimer’s disease, the most common cause of dementia, is one of the key challenges for modern science, and a research team in the US might have made a significant breakthrough. The team’s paper, Gamma frequency entrainment attenuates amyloid load and modifies microglia, was published at the end of…
New Paper: Mesoscale-duration activated states gate spiking in response to fast rises in membrane voltage in the awake brain
Published Tue, 01 Aug 2017 in Journal of Neurophysiology “Seconds-scale network states, affecting many neurons within a network, modulate neural activity by complementing fast integration of neuron-specific inputs that arrive in the milliseconds before spiking. Nonrhythmic subthreshold dynamics at intermediate timescales, however, are less well characterized. We found, using automated whole cell patch clamping in vivo, that…
Killing the Mind First
By Ben Brumfield | Published July 6, 2017 “When George Wright buried his wife, Beth, in 2013, he was probably easing into the same illness that had killed her at age 84. But his adult children hadn’t yet noticed that he, too, had Alzheimer’s disease. Their eyes had been fixed on their mother while her mind unraveled,…
Congratulations to Abby Paulson for winning the Elder Health Scholarship
Abby Paulson won the Elder Health Scholarship from the Residential Care Facilities for the Elderly Authority of Fulton County for her outstanding academic record and her commitment to and potential for leadership in the field of aging.
Full Post Congratulations to Abby Paulson for winning the Elder Health Scholarship
Cosmos in the Cranium
Article By Ben Brumfield “The human brain is believed to have more than 160 billion cells; more than half of them are neurons. And they often share thousands of connections with neighboring neurons to form somewhere between 100 trillion and a quadrillion circuits flashing day and night. That’s many hundreds of times more circuits than there…
A New Way to Approach Alzheimer’s: From the Beginning
A new article about our research: Story by Lyndsey Lewis Photos by Gary Meek “Annabelle Singer’s research could revolutionize the way we look at the disease’s progression. If you keep up with medical news, you’ve probably heard of beta amyloid. It plays the villain in plenty of stories about Alzheimer’s disease: One of the signature…
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New paper: An innovative and groundbreaking approach to combating Alzheimer’s
Newly published in Nature : “Gamma frequency entrainment attenuates amyloid load and modifies microglia.” Disrupted gamma rhythms—oscillations in the brain’s neuronal circuits at around 20–50 Hz—are hallmarks of various neurological disorders and have been seen in patients with Alzheimer’s disease and specific mouse models of the disease. We show that gamma oscillations are also disrupted…
Full Post New paper: An innovative and groundbreaking approach to combating Alzheimer’s
Bettina Arkhurst won the Laya Wiesner Award
Congratulation to Bettina Arkhurst who was awarded the Laya Wiesner Community Award.
Recording robots are in the news
In Nature, Helen Shen writes about robots recording brain activity inside neurons highlighting our work.