Singer Lab

Decoding Memory In Health and Disease

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Decoding Memory in Health and Disease

Our lab’s long-term goal is to understand how neural activity both produces memories and protects brain health, while using this knowledge to engineer neural activity to treat brain diseases. Our lab studies how coordinated electrical activity across many neurons represents memories of experiences, how this activity fails in animal models of Alzheimer’s disease, and how engineering neurons to produce this activity has neuroprotective effects and engages the brain’s immune system. Integrating innovative experimental and analytical methods, this research will provide unprecedented insight into how neural activity failures lead to memory impairment and will reveal novel ways to engineer neural activity to repair brain function. Using non-invasive approaches, we translate these discoveries from rodents to humans. These insights could lead to radically new ways to treat diseases that affect memory like Alzheimer’s, for which there are no effective therapies.

 

JOIN THE LAB

We are seeking highly motivated and innovative graduate students and post-docs. Individuals with engineering, computational, or neuroscience experience are welcome.  Potential post-doctoral fellows , please contact Dr. Singer to discuss further and be sure to include a cover letter and CV or resume with your correspondence.  Potential graduate students, please apply to the Biomedical Engineering (BME) PhD program at Georgia Tech and Emory or apply to the Neuroscience PhD program at Emory.

NEWS

Singer has received a Gilbreth Lectureship from the National Academy of Engineering (NAE) and will present her work on neural stimulation for Alzheimer’s patients at the Academy’s 2022 national meeting in Irvine, California.  Read more here The Gilbreth Lectures were established in 2001 by the Council of the National Academy of Engineering as a means […]

Congratulations to Dr. Tina Franklin for being awarded an Alzheimer’s Association Research Fellowship! Thank you  Alzheimer’s Association for supporting this groundbreaking research at the intersection of stress, inflamm-aging, and neurodegenerative disease.

Big congratulations to Stephanie Prince for being awarded the Emory Neuroscience Program Scholar of the year AND Outstanding Scientific Achievement Award!  Steph has some very cool science in the works. Check out her paper from earlier this year here.  

The American Neurological Association has recognized Annabelle Singer for achieving significant stature in neurological research and demonstrating the promise of major contributions to come. Singer has received a Derek Denny-Brown Young Neurological Scholars Award from the association and will deliver a talk about her work virtually in October at the association’s 2021 national meeting. Read […]

Our human trial of gamma sensory stimulation or “flicker” in human Alzheimer’s patients based on our animal studies is now published:  https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12178 This was an illuminating (pun intended) collaboration the clinical team at EmoryBrain Health Center led by James Lah and Allan Levey and the Wood lab and Singer lab at Georgia Tech. In planning the […]

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