Check out our new paper: “Multisensory flicker modulates widespread brain networks and reduces interictal epileptiform discharges” https://rdcu.be/dEtHG led by Lou Blanpain.
Lou discovered how *human* neural circuits respond to sensory flicker stimulation and how sensory stimuli effect pathological epileptiform activity. In a series of clever experiments, Lou reveals new mechanisms of sensory evoked responses far beyond canonical sensory brain regions. Using high spatiotemporal resolution intracranial recordings in human subjects, Lou established that flicker affects neural activity across widespread brain structures, including those implicated in cognition and disease such as the medial temporal lobe. Because such widespread sensory-driven activity is unexpected, we asked how this rhythmic response comes about. Mechanistically, our findings show that flicker-induced responses emerge from resonance of circuits rather than a simple summation of sensory responses. We were surprised that flicker decreases the overall rate of IEDs, pathological activity
that is associated with epilepsy and has an increased prevalence in many brain diseases such as AD, autism, attention deficit hyperactivity disorder (ADHD), and multiple sclerosis. Thus, this work highlights multisensory flicker as a new non-invasive method to manipulate rhythmic activity and decrease pathological activity in humans.
Read more here: https://news.gatech.edu/news/2024/05/09/flicker-stimulation-shines-clinical-trial-epilepsy
Read the full paper here: https://rdcu.be/dEtHG
