Congratulations to Anthony Martorell (Li-Huei Tsai’s lab) and Abby Paulson (my lab), co-first authors of this cool new paper in Cell. In short: auditory + visual sensory flicker stimulate rhythmic activity in deep brain regions that are hard to reach with existing non-invasive stimulation, like the hippocampus and prefrontal cortex. Gamma frequency multi-sensory flicker (but not other frequencies) reduces amyloid beta, effects microglia, astrocytes, and vasculature, and boosts memory performance in mice. This builds on our prior paper but now shows how to stimulate non-invasively to target regions implicated in Alzheimer’s and shows many more effects of gamma stimulation.
