Newly published in Nature : “Gamma frequency entrainment attenuates amyloid load and modifies microglia.”
Disrupted gamma rhythms—oscillations in the brain’s neuronal circuits
at around 20–50 Hz—are hallmarks of various neurological disorders and
have been seen in patients with Alzheimer’s disease and specific mouse
models of the disease. We show that gamma oscillations are also
disrupted in the 5XFAD mouse model of Alzheimer’s disease, and find
reduced gamma prior to plaque formation and cognitive decline.
Remarkably, by training neurons to oscillate at gamma frequency (40
Hz) in multiple mouse models including APP/PS1 and wild-type mice,
amyloid-β peptide levels could be reduced.