*co-first authors ++co-corresponding authors click on doi:*** for link to article
Non-invasive 40 Hz light flicker to reduce amyloid load and recruit microglia.
Singer AC++, AJ Martorell, JM Douglas, F Abdurrob, M Attokaren, J Tipton, H Mathys, C Adaikkan, and L-H Tsai++ (accepted)
Multi-neuron intracellular recording in vivo via interacting autopatching robots.
Kodandaramaiah SB*, FJ Flores*, GL Holst, AC Singer, X Han, EN Brown, ES Boyden, CR Forest (2018)
Evidence for long-timescale patterns of synaptic inputs in CA1 of awake behaving mice.
Kolb I*, Franzesi GT*, M Wang, SB Kodandaramaiah, CR Forest, ES Boyden ++, AC Singer ++ (2017)
Journal of Neuroscience.
doi: https://doi.org/10.1523/JNEUROSCI.1519-17.2017. PMID: 29279309
Illuminating Neural Circuits: From Molecules to MRI.
Lee JH, A Kreitzer, AC Singer, N Schiff (2017)
Journal of Neuroscience, featured article on symposium in Annual Meeting issue
doi: https://doi.org/10.1523/JNEUROSCI.2569-17.2017. PMID: 29118210
Mesoscale activated states gate spiking in the awake brain.
Singer AC*, GT Franzesi*, SB Kodandaramaiah, Cohen JD, Lee AK, Borgers C, Forest CR, NJ Kopell, ES Boyden (2017)
Journal of Neurophysiology.
doi: 10.1152/jn.00116.2017. PMID: 28566460.
Gamma oscillations attenuate amyloid pathology and trigger a distinct microglia response in a mouse model of Alzheimer’s disease.
Iaccarino HF*, Singer AC*, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai L-H (2016)
doi: 10.1038/nature20587. PMID: 27929004.
Published with News and Views. Recommended on Faculty of 1000.
Autopatching: assembling and using a robot for automated intracellular neural recording in live mammalian brain.
Kodandaramaiah SB, IR Wickersham, GB Holst, AC Singer, G Talei-Franzesi, CR Forest, ES Boyden (2016)
doi: 10.1038/nprot.2016.007. PMID: 26938115.
Principles of Designing Interpretable Optogenetic Behavior Experiments.
BD Allen*, Singer AC*, ES Boyden (2015)
Learning and Memory.
doi: 10.1101/lm.038026.114. PMID: 25787711.
Hippocampal SWR activity predicts correct decisions during the initial learning of an alternation task.
Singer AC, MF Carr, MP Karlsson, LM Frank (2013)
doi: 10.1016/j.neuron.2013.01.027. PMID: 23522050.
Experience dependent development of coordinated hippocampal spatial activity representing the similarity of related locations.
Singer AC, MP Karlsson, AR Nathe, MF Carr, LM Frank (2010)
Journal of Neuroscience.
doi: 10.1523/JNEUROSCI.0926-10.2010. PMID: 20810880
Rewarded outcomes enhance reactivation of experience in the hippocampus.
Singer AC and LM Frank (2009)
doi: 10.1016/j.neuron.2009.11.016. PMID: 20064396.
Selected Press Highlighting Our Research
Windell J (2017) What’s the Frequency? The Biomedical Scientist.
Lewis L (2017) A New Way to Approach Alzheimer’s: From the Beginning. Georgia Tech Engineers.
Webster M (2016) “Bringing Gamma Back.” Radiolab.
Yong E (2016) “Beating Alzheimer’s With Brain Waves.” The Atlantic.
Zakaib G (2016) “Flashy Treatment Synchronizes Neurons, Lowers Aβ in Mice.” ALZForum.
Healy M (2016) “Flickering lights may illuminate a path to Alzheimer’s treatment.” LA Times.
Roberts M (2016) “‘Flashing light therapy’ for Alzheimer’s.” BBC News.
Aron L & Yankner BA (2016) “Neurodegenerative disorders:
Neural synchronization in Alzheimer’s disease.” Nature 540, 207–208.
Singer W (2016) “F1000Prime Recommendation of Iaccarino HF, Singer AC et al. Nature 2016.” F1000Prime.
Hughes V (2014) “Mental Leaps Cued by Memory’s Ripples.” Quanta Magazine.
Robinson A (2014) “MIT Neurotech: Tapping into Neurons with Autopatching.” Scientific American.
Eichenbaum H (2013) “Hippocampus: remembering the choices.” Neuron, 77(6): 999–1001. Preview article.
Wagstaff K (2012) “Robot That Connects to Neurons Could Provide Key to Understanding the Human Brain.” Time.
Peer Reviewed Conference Presentations
Kolb I*, GT Franzesi*, M Wang, SB Kondandaramaiah, CR Forest, ES Boyden, AC Singer (2017) “Repeated membrane potential patterns in the hippocampus of awake mice are related to spiking.” Poster Presentation at Computational and Systems Neuroscience Conference (Cosyne), Salt Lake City.
Aksel DC, SB Kondandaramaiah, AC Yang, AC Singer, GT Franzesi, ES Boyden (2015) “An Image-Guided Platform For Automated Whole-Cell Patch Clamping Of Cells In Culture.” Oral Presentation at Biomedical Engineering Society Annual Meeting, Tampa 2015.
Singer AC*, GT Franzesi*, SB Kondandaramaiah, M Tsitsiklis, D Bozic, S Sharma, S Batir, IR Wickersham, G Holst, CR Forest, C Borgers, NJ Kopell, ES Boyden (2015) “Time course of subthreshold activity preceding spike generation in awake behaving mouse.” Poster Presentation at Computational and Systems Neuroscience Conference (Cosyne), Salt Lake City 2015.
Singer AC, GT Franzesi, SB Kondandaramaiah, IR Wickersham, M Tsitsiklis, D Bozic, S Sharma, S Batir, N Pak, G Holst, CR Forest, NJ Kopell, ES Boyden (2013) “Awake Autopatching: Automatic whole cell patch clamp of hippocampal neurons in awake behaving animals.” Invited talk for MIT Brain Lunch series, MIT, Cambridge, 2013.
Singer AC, MP Karlsson, AR Nathe, MF Carr, LM Frank (2010) “Coordinated hippocampal firing across related spatial locations develops with experience.” Selected for oral presentation at Computational and Systems Neuroscience Conference (Cosyne), Salt Lake City 2010.
Singer AC and LM Frank (2009) “Reward enhances reactivation of experience in the hippocampus.” Selected for oral presentation at Gordon Research Conference on Neural Circuits and Plasticity, Newport 2009.
Singer AC and LM Frank (2009) “Reward enhances reactivation of experience in the hippocampus.” Selected for oral presentation at Computational and Systems Neuroscience Conference (Cosyne), Salt Lake City 2009.
Invited talks at DBS Think Tank 2018, MIT Symposium “Brain Rhythms in Health and Disease,” “Mechanisms of Learning Forum” at Emory University, NIH Symposium: “Innovations in Imaging to Advance Aging Research,” Society for Neuroscience symposium “Illuminating Neural Circuits: From Molecules to MRI,” Harvard Medical School, Princeton University, Janelia Farm Research Campus of the Howard Hughes Medical Institute, Georgia Institute of Technology, Brown University, Boston University, Emory University, Massachusetts Institute of Technology, the Memory and Aging Center at UCSF, and the Center for Visual and Neurocognitive Rehabilitation at the U.S. Department of Veterans Affairs.